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OP asks for small thing, most replies ask for huge things.
I guess the opposites of small thing and biggest positive impact on the world makes it hard to answer.
Inherent self interest disappears. People work for the greater good.
Psychologically that would be a desaster. People would wear themselves out in an instant, and in 6 months top we’d have a world population suffering from clinical depression.
Kill all humans
People being fucking allergic to animal products, like at all. Or finding the taste naturally disgusting
Simple. True empathy for everyone. Literally feeling what others feel
So every time someone stubs their toe, every other human would feel the pain? Everyone would be completely overwhelmed by all kinds of feelings all the time.