You can install silverblue, and then rebase to ublue ( https://universal-blue.org/ ). Specifically to the “silverblue-nvidia” variant, and you should get a nice silverblue experience without any of the nvidia struggles, as people at the ublue project take care of that stuff for you.

And yes, distrobox is the goto solution to run stuff that is basically ubuntu-only, or by extension bound to any distro variant / version and not flatpak. This includes graphical applications. Distrobox works great, I do all my work in it.