Not too long ago, regulations on CBD changed in Germany leading to a plethora of products containing it. As someone who occasionally needs pain medication, I tried some of the products to avoid regular pain killers (ibu). Especially on days with lighter pain, I wished for an alternative to the sledgehammer meds. But I was left standing in the rain. I didn’t feel any effect. That’s why I would love to hear from your experiments and experience.

  • Hot Saucerman@lemmy.ml
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    1 year ago

    I’m having trouble finding it, but I ran across a study a few months ago whose results pointed to greater pain relief gains when CBD was consumed with THC, and that both substances alone do less to “relieve” pain.

    I wouldn’t say it helps relieve pain as much as it lets you be distracted from pain.

    Also, personally, when I have used CBD on it’s own, it never did anything for me at all. It only ever worked in combination with THC.

    Finally, people taking other medications need to be careful about taking CBD.

    The vast majority of medications are broken down by enzyme CYP3A4, an enzyme that CBD inhibits.

    I am taking a life-saving/life-altering medication to manage a severe disease. It is handled in my body by CYP3A4. Meaning I can really fuck up my medication dosage by taking CBD on its own, because it will inhibit the ability of CYP3A4 to ingest the drug.

    User pizza_rolls@kbin.social helpfully pointed out that grapefruit inhibits CYP3A4 as well, so if you’re not supposed to eat grapefruit, you should probably also avoid CBD. I hadn’t even made that connection myself, very astute, pizza_rolls!

    • FUsername@feddit.deOP
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      1 year ago

      Thank you for pointing that out! In I’m in the happy place of not having to take anything else on a regular basis, but it sure makes sense to keep the heads up of required.

  • Today@lemmy.world
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    1 year ago

    You can’t think about what you feel; you have to think about what you don’t feel. What’s gone or lessened - anxiety, irritability, general discomfort, insomnia, etc.? Also, you have to be careful where you get it. For oils i like Lazarus naturals and Hoku Seed Co. Not sure if either so outside the US. It may take a bit for youto get max benefit from it - almost the inverse of thc tolerance.

    • FUsername@feddit.deOP
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      1 year ago

      Thank you! As a human, I’m excellent in leaving behind what bugs me in an unpleasant way until it hurts on a level I cannot ignore.

      The thing with THC tolerance is also interesting. Does a CBD/THC mixture remain equally effective of the percepted effects of both constituents have mirrored tolerance/effect characteristics?

  • cerement@slrpnk.net
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    1 year ago

    the problem is the legality of other cannibinoids where you live …

    • from the states in the US where cannabis has been legalized – neither CBD nor THC will show their full effects in isolation, they each help to augment the other – so even something like a tiny amount of THC added to CBD (ex. 20:1 CBD to THC) will drastically enhance the CBD effects
    • there are two primary (and a lot of secondary) pain systems within the body – one of them responds better to opioids, the other responds better to cannibinoids cannabinoids – everyone’s different and responds differently so it requires a knowledgeable medical professional who hasn’t bought into US’s “reefer madness” propaganda that’s been foisted off onto the rest of the world
    • FUsername@feddit.deOP
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      1 year ago

      Thank you for your balanced thoughts! Well your first point kinda might be an issue. I guess I haven’t dived deep enough into this topic to answer whether these mixtures are legally available here. Speaking of it: can you (or someone you know 😉) feel any psychedelic effect of the THC with a 20:1 ratio?

      I tried to convince trained professionals twice to go the mentioned route with me. Instead, the looked for me as if I asked for a roofie on the house. So that is another issue…

  • AttackBunny@lemmy.world
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    1 year ago

    Chronic migraine sufferer here. Like 25+ days a MONTH, over 5 on the pain scale, plus all the other fun symptoms.

    I had tried literally every other drug on the market for migraine, even some off label, except Botox. The newest class of migraine drugs wasn’t on the market yet. History tells me I likely will not do well with Botox, so as a last ditch effort, before trying it, I decided to experiment with weed again.

    Life changing is an understatement. Went from most of the month, where I felt like I was slowly dying, to having MAYBE 2 relatively mild migraines per YEAR.

    Certain strains work better for me as an abortive, than others, but just having it in my system daily gave me my life back. It doesn’t seem to matter whether is a 1:1 (CBD:THC) or just a regular old mostly THC strain, it just works for me.

      • AttackBunny@lemmy.world
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        1 year ago

        Honestly, I don’t even need to get stoned for it to help. Just a small puff off the vape, once a day, and I’m good to go. I haven’t bothered to try playing with the not thc stuff.

        The rare instance a migraine starts, at least weed is an incredibly predictable thing. A migraine can range from “eh I can power through” to “hmmm Half the vision in my right eye is gone”. I’ll take being stoned lol.

        • FUsername@feddit.deOP
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          1 year ago

          From what you write, stoned is a positive side effect of the whole thing isn’t it? Out do you think this is the main aspect of why the migraine is so much better bearable to you?

  • AFK BRB Chocolate@lemmy.world
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    1 year ago

    My wife has chronic neuropathic pain, and the CBD gummies seem to help her sleep. They don’t seem to overtly reduce the pain, but maybe make her less anxious about it.

    • FUsername@feddit.deOP
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      1 year ago

      Thank you! I think, this is an aspect I tend to underestimate: the anxiousness pain causes. It is not affecting me much of what I experience, but deep down, it is a thing.

  • Marleyinoc@lemmy.world
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    1 year ago

    I think you need to find your dosage and stay on it to help with inflammation which can also reduce pain. I took a lot when I lifted weights regularly. But I ended up making it myself to make it affordable.

    I’d use a reputable company. Some seem to try to keep costs down–I sometimes would buy theirs for convenience. (I would use an decarb/infusion machine and eventually bought an extraction machine. Basically cold alcohol wash hemp then evaporate the alcohol back out).

    • FUsername@feddit.deOP
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      1 year ago

      Thank you! This gives me some highschool vibes of chemistry. The useful aspects of it at least. Is it fool safe or would you recommend starting with ready products?

      • Today@lemmy.world
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        1 year ago

        Weed in jar. Jar in freezer. 190 proof ethanol in freezer. Next day- mix, shake, freezer for one Netflix show, strain through strainer, strain through cheesecloth or coffee filter. Use an electric (NOT GAS!) appliance (rice cooker, crock pot, air fryer, dehydrator, or fan) to evaporate the alcohol. When you have a dark, sticky goo, add a little coconut oil for viscosity and heat to 250f, stirring occasionally until the tiny carbonation bubbles slow down.

        • FUsername@feddit.deOP
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          1 year ago

          Thank you for you recipe! That sounds manageable - as soon as the base substance is legally available here 😉 I will keep an eye on that - it is supposed to be anytime soon…

  • Shdwdrgn@mander.xyz
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    1 year ago

    My wife and I both have lives now because of it. In my case, I have body aches from a bad car wreck, and after ten years of only getting maybe 3 hours of good sleep each night, followed by prescribed meds that left me dopey all day long, marijuana was legalized here. My wife makes CBD cookies for me and after a bit of experimenting to get the right amount, I now generally wake up feeling refreshed and have even been needing less sleep for the last several years.

    On the other hand, my wife lives with chronic pain from childhood accidents including one where she was partially paralyzed for a few years (spine injuries suck!). She is now on permanent disability because she wasn’t able to sit at a desk for 8 hours a day. Since mj was legalized, she got off the opioids, smokes throughout the day to manage the pain as needed, but is able to get things done around the house when she’s having good days (which is most of the time).

    If you want to go down this road, you will definitely get a better experience than you have with doctor-prescribed medications, however because there’s still not a lot of data on the subject you will want to find what works for YOU. If you do any cooking, learn how to make oil and butter from mj, and use that to bake your own cookies, cakes, or whatever. This way you have control over what strains go in to what you are eating, and you can control how much of it is used. You can get instruments to be more scientific with it, but really once you have some experience with CBD/mj it won’t really matter. It also tends to be quite a lot cheaper than buying pre-made edibles from the store.

    Now, for what to expect… For my use, the right amount is something that I barely feel, if at all. What I do notice is once it starts to kick in (which is right before bed anyway), I start to drift off and have to make an effort to get up and go to bed. If I eat too much then yeah, things can start to get a bit crazy, and I don’t get as good of sleep that night. For my wife managing her pain, she describes it by saying the pain doesn’t really go away, she just stops caring about it so it doesn’t control her life. Again, the right amount isn’t so much that she acts like a stoner all the time (and she consumes a LOT more than I do), but rather it’s enough that she can start to function again despite the pain. So it’s not unusual for you to not feel anything, but it’s also possible you’re simply not getting enough.

    Hope that helps?

    • FUsername@feddit.deOP
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      1 year ago

      Yeah, thank you! As far as I understand what you describe, your therapy is not solely based on CBD but also a not irrelevant fraction of THC, am I getting that right? Honestly I’m a little scared to go that route, but I’m really happy it held you so much!

  • Teknikal@lemmy.world
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    1 year ago

    It has an effect but the price for that effect is insane (at least in the UK) . It isn’t an instant thing you need to keep taking it for at least a few weeks.

    Definitely made me much calmer but like I said not at that price.

    • FUsername@feddit.deOP
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      1 year ago

      Thank you for your report! Yeah money is also an aspect. In Germany and I think EU (sorry bro) they start seeking it as a drug in pharmacies. If I found it to be of any help to me, I wished I found a way like getting my health insurance passing for it 😜 Don’t you have any similar options?

  • Semmelstulle@feddit.de
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    1 year ago

    Well I bought CBD a few times now and roll it like a cigarette. It relieves stress very well and calms down - that’s basically all CBD does. I can not handle THC but I have great experience with a CBD cigarette once every 6 months or so.

      • Semmelstulle@feddit.de
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        1 year ago

        Well, the few times I tried THC I always have been invited, so I don’t know the ratio. And the CBD I sometimes get is from Austria. They never said anything about THC on it, if I’m not mistaken. But from what I know, only female pants produce the THC, so it should always have been as THC reduced as the plant can grow it.

        Edit: was hard to read, I made the sentences more easy on the eye.

        Edit 2: just realized you’re a Feddit.de user, too!

    • fades@beehaw.org
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      1 year ago

      that’s basically all CBD does

      Yes but there is also more to CBD, it also relieves pain, helps with inflammation, insomnia, etc too.

      People should know it’s not just CBD anymore, there is CBG, CBN, etc. as well that are just as helpful in slightly unique ways

  • Jim@lemm.ee
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    1 year ago

    This is a tricky question. I’m inclined to have a positive opinion about CBD, but if I’m completely honest I don’t feel much of anything from it solo. I’ve taken CBD by itself multiple times and it always just seemed like a placebo. I think CBD and THC together have a great synergy, but it really misses the mark when I only have the one without psychoactive effects.

    On the other hand, I’ve had friends swear by CBD tinctures. They were doing large doses (like 50mg+) daily and claimed it had all sorts of benefits for their chronic pain or upset stomach. I never tried doing doses that big regularly just because of the cost and my previous experiences leaving me dissatisfied.

    For what it’s worth, Extract Labs is one of the sources I’ve had recommended to me by a trusted friend.

    • FUsername@feddit.deOP
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      1 year ago

      Thank you for passing on the recommendation! I’m a little scared to go with any significant fraction of THC… Maybe my dose was just too low so far.

  • Proteus@lemmy.world
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    1 year ago

    I recently got a medical card for cannabis. during the call, the doctor said to use a CBD:THC combo for the best results on pain relief. seems to be working well for me.

  • erogenouswarzone@lemmy.ml
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    1 year ago

    Me, personally, I noticed an effect. However, I’ve never been a potist.

    I used it for when I was sick. I got some flavored oil and put a few drops under my tongue occasionally.

    Yes, it helped calm me down. But, I was hungover after I stopped taking it. But I get hangovers very easily because my liver has lived a few lives at this point - I was a bit of an alcoholist.

    • FUsername@feddit.deOP
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      1 year ago

      Thank you! Does calm down also refer to some pain felt or was it rather recreational?

      But more importantly: the past tense in your last sentence sounds like you are still going strong without. If so: an internet stranger is proud of you!