Conclusion

Our study provides novel evidence for an positively and independently association between specific blood VOC exposures and the risk of developing OAB in U.S. adults, with blood furan being the most significant.

The results indicated that long-term exposure to VOCs may lead to an increased risk of developing OAB in adults, especially blood 2,5-dimethylfuran, benzene and furan. In addition, the concentration association between blood 2,5-dimethylfuran, benzene and furan and OAB risk suggests that long-term exposure to VOCs may lead to an increased risk of OAB, especially in the initial period presenting a significant increase.

The risk of OAB occurrence is more likely to be influenced by blood VOCs in certain specific populations, including young and middle-aged, male, non-hypertensive, and alcohol-drinking populations.

Finally, more prospective and experimental studies are needed to further validate the conclusions of this study and explore the pathological mechanisms.