On Earth, the cardinal directions are straightforward. The arrow on a compass points to the nearest magnetic pole. You can then use it to travel anywhere on Earth.
In space, the idea of anything being “central” enough to be used as a “North” (since the universe has no center) or being fixated enough to not somehow pose issues is more convoluted.
If you were a pioneer of space exploration, what would your “North” be?
Probably arbitrarily one of the two vectors perpendicular to the plane of the Milky Way? (Assuming it wasn’t necessary for this navigation system to work outside of our galaxy.)
But seriously, even so, I think it’d be reasonable to still have per-galaxy navigation systems.