I’ve never attempted this before, so I’m not sure how helpful I’ll be, but I did find the following resource that seems to insist it is feasible: https://www.addictivetips.com/ubuntu-linux-tips/space-engineers-linux/
Additionally, this Q&A looks to cover a more recent resource that could be helpful, to which the Github is located here: https://github.com/Matoking/protontricks
I will say the game runs fairly well on Windows, but if you play with a lot of mods, it regularly encounters problems. Historically speaking, I re-install and/or fix my SE installation many times a year. So if it makes you feel better, encountering problems while attempting to run the game is a fairly regular experience to some degree.
If you like PAM, you may also enjoy taking a look at SCAM! It has a crazy cool, fully visual and interactive, in-game interface. You can control multiple drones with it to mine out asteroids.
https://steamcommunity.com/sharedfiles/filedetails/?id=2572154209