[DNA macroarray analysis of gene expression changes in rat brain after single administration of 2-aminoadamantane compound] - PubMed
pubmed.ncbi.nlm.nih.gov
We have used the Rat Atlas cDNA Array ("BD Bioscience") to assess changes in mRNA expression of 588 genes in rat brain after acute treatment of 2-aminoadamantane compound--Ladasten. Drug exhibits the psychostimulating and anxyolitic actions. The analysis of results of hybridization on macrochips and …

This is a study of the nootropic drug Bromantane, showing long lasting epigenetic changes after a single dose. Although there is no evidence the drug has a similar effect in humans, the anecdata in /r/nootopics and /r/nootropics tends to report long lasting effects even after discontinuation of the drug. There are many reports saying things like “this is the best ADHD drug I’ve ever tried”, etc, suggesting the obvious conspiracy theory that sub-par drugs are prescribed because they are patented and profitable, compared to this Soviet drug from the 80s.